Y., Tseng S. CSE-induced apoptosis, which is likely through a CHOP-independent pathway. Surprisingly, knockdown of CHOP reduced p-eIF2 and Nrf2 resulting in a designated increase in caspase-3 activation and apoptosis. Furthermore, Nrf2 inhibition improved ER stress and exacerbated cell apoptosis, while Nrf2 overexpression reduced CHOP and safeguarded RPE cells. Our data suggest that although CHOP … Continue reading Y